Table of Contents
January 01, 2026; Volume 93, Issue 1-
From the Editor
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More on the myths and perceived magic of corticosteroids
Brian F. Mandell, MD, PhD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 6-7;
- DOI: https://doi.org/10.3949/ccjm.93b.01026
It is widely accepted that corticosteroids can partially prevent infusion reactions to intravenous diagnostic and therapeutic agents, but evidence to support this concept is scant.
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The Clinical Picture
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Multicentric reticulohistiocytosis
Atul Khasnis, MD, MS and Joseph M. Dyer, DO- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 9-11;
- DOI: https://doi.org/10.3949/ccjm.93a.24124
A 58-year-old man presented with a 2-month history of joint pain and swelling and a rash.
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Pseudoxanthoma elasticum
Kathleen Kramer, MD, Sama Alazawi, DO and Rudy Schmiedecke, MD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 13-14;
- DOI: https://doi.org/10.3949/ccjm.93a.25021
The patient presented for evaluation of yellowish plaques on her neck that had been present since childhood.
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1-Minute Consult
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Atrial fibrillation in patients with obesity: How can we optimize management?
Asim Kichloo, MD, Ivan Magallanes Marrufo, MPH and Suhaib Andrabi, MD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 17-20;
- DOI: https://doi.org/10.3949/ccjm.93a.25032
Heart rate and rhythm control therapies often must be adjusted when treating patients with obesity, while other measures can reduce the onset or recurrence of atrial fibrillation.
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Commentary
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Vaccine hesitancy: Where are we heading?
Sherif Beniameen Mossad, MD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 21-26;
- DOI: https://doi.org/10.3949/ccjm.93a.25104
Vaccination recently was hailed as one of the top 10 public health achievements of the 20th century; now, the World Health Organization lists vaccine hesitancy among the top 10 threats to global health.
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Symptoms to Diagnosis
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A young woman with Kallmann syndrome and acute neurologic symptoms
Jumaina F. Ali, MBChB, Adhithya Sankar, MBChB, PhD, Mohammed S. O. Ahmed, MBBS, MSc, Mark Woodward, BSc (Hons), MBChB and Akheel A. Syed, MBBS, PhD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 29-34;
- DOI: https://doi.org/10.3949/ccjm.93a.25010
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
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Current Drug Therapy
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Update on antiobesity pharmacotherapy in adults: Current and emerging options
Farah Ziyadeh, MD, Sara Saliba, MD, RD, Dania Salih Bacha, MD, Yael Mauer, MD, MPH, Marcio L. Griebeler, MD, DABOM and Bartolome Burguera, MD, PhD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 36-46;
- DOI: https://doi.org/10.3949/ccjm.93a.24112
The authors review antiobesity medications that are currently available or under investigation and discuss how to personalize obesity treatment.
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Review
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Do corticosteroids prevent reactions to infusions of contrast, monoclonal antibodies, or chemotherapy?
Dylan T. Timberlake, MD, Sushmitha Boppana, MD and James Fernandez, MD, PhD- Cleveland Clinic Journal of Medicine January 2026, 93 (1) 47-53;
- DOI: https://doi.org/10.3949/ccjm.93a.25026
The data and recommendations about corticosteroid pretreatment vary by medication class and the individual medication, necessitating a medication- and patient-specific approach.
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