Table of Contents

April 01, 2026; Volume 93, Issue 4
  • From the Editor

  • The Clinical Picture

      • Palatal mass with an overlying white lesion

        Takuma Watanabe, DDS, PhD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 199-200;
        • DOI: https://doi.org/10.3949/ccjm.93a.25050
        • The patient had no symptoms related to the mass, and computed tomography did not show any notable abnormalities.

  • Guidelines to Practice

      • Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options

        Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205;
        • DOI: https://doi.org/10.3949/ccjm.93a.25052
        • In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • Editorial

  • Symptoms to Diagnosis

      • A 20-year-old woman with a 9-year history of shortness of breath

        Jack Johnson, OMS-1, Karishma Lukose, MS4 and Mary C. Labanowski, MD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 211-217;
        • DOI: https://doi.org/10.3949/ccjm.93a.25073
        • The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.

  • Interpreting Key Trials

      • Interpreting the DIGIT-HF trial: Time for a new look at digitalis?

        Enmanuel A. Leiva-Murillo, MD, Oriol Ventosa-Blázquez, MD and Eduard Solé-González, MD, PhD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 218-226;
        • DOI: https://doi.org/10.3949/ccjm.93a.25098
        • Digitoxin reduced the risk of death or first hospitalization for heart failure in patients with symptomatic heart failure with reduced ejection fraction who were already being treated with guideline-directed medical therapy.

  • Review

      • Complement inhibition: A whole new world

        Nicholas Salupo, DO, Korey Bartolomeo, DO, Elias Bassil, MD, Corey Cavanaugh, DO, Georges Nakhoul, MD, MEd, Jonathan Taliercio, DO and Ali Mehdi, MD, MEd
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 227-236;
        • DOI: https://doi.org/10.3949/ccjm.93a.25076
        • As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.

  • Editorial

      • Clinical application of the complement system: A historical perspective

        Adam J. Brown, MD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239;
        • DOI: https://doi.org/10.3949/ccjm.93a.26014
        • Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • Review

      • TOC Icon

        Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care

        CME Image
        Magnus Chun, MD, Amrit Narwan, MD, Ryan Parto, MD, Andrew John Cruz, MD, Jiayi Ge, MD, Zan Ferrin, DO, Namrita George, DO, Evelyn Kue, DO, Adam Khattak, DO, Vignan Manne, MD and Amber Champion, MD
        • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 241-248;
        • DOI: https://doi.org/10.3949/ccjm.93a.25054
        • Gastrointestinal disorders are common in patients with diabetes mellitus and can be linked to diabetes itself, its complications, or medications used to treat it.

  • Letters to the Editor