Table of Contents

May 01, 2026; Volume 93, Issue 5
  • From the Editor

      • ‘Even when the wound is healed, the scar remains’

        Brian F. Mandell, MD, PhD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 255-256;
        • DOI: https://doi.org/10.3949/ccjm.93b.05026
        • Persistent or repetitive inflammatory or ischemic insults to internal organs may lead to progressive scarring that culminates in organ failure.

  • The Clinical Picture

      • Iris roseola: A diagnostic clue in neurosyphilis

        Victor Alegre-Ituarte, MD, PhD and Elena Franz-Lacomba, MD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 259-260;
        • DOI: https://doi.org/10.3949/ccjm.93a.25047
        • The patient had a 3-week history of decreased vision in the left eye, with a best-corrected visual acuity of 20/100.

      • Varicella-zoster virus transmission from herpes zoster exposure

        Ayano Takeiri, MD, Kentaro Ishikura, MD and Yoshitaka Tomoda, MD, PhD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 261-262;
        • DOI: https://doi.org/10.3949/ccjm.93a.25068
        • Two weeks before the patient developed fever and a rash, his mother had developed herpes zoster on her torso.

  • Commentary

      • Fighting ageism: Preserving patient agency in critical care

        Astefanos Al-Dalakta, MD, Ruth Diana Lee, MD, Chadi Tabaja, MD, Issam Motairek, MD and Eduardo Mireles-Cabodevila, MD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 263-265;
        • DOI: https://doi.org/10.3949/ccjm.93a.25105
        • To avoid falling into ageism bias, we must maintain a framework grounded in respect for the patient, one that deliberately centers on the patient’s voice.

  • Symptoms to Diagnosis

      • Unexplained liver injury: Searching for the cause

        Mohamed Eldib, MD, William D. Carey, MD and Blazenka Skugor, MD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272;
        • DOI: https://doi.org/10.3949/ccjm.93a.25099
        • The patient presented with persistent low back pain, nausea, poor appetite, and an unintentional weight loss of more than 30 lb over the previous 6 weeks.

  • Interpreting Key Trials

  • Review

      • Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight

        CME Image
        Leandro Sierra, MD, Lily Liu, MD, Akash Khurana, MD, Roma Patel, MD, Arjun Chatterjee, MD, Stephen Firkins, MD and Roberto Simons-Linares, MD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286;
        • DOI: https://doi.org/10.3949/ccjm.93a.25082
        • Weight loss of at least 10% is associated with fibrosis regression in most patients, but losing this amount of weight and keeping it off is challenging, making pharmacologic and procedural interventions essential tools in clinical practice.

      • TOC Icon

        Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know

        Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 289-295;
        • DOI: https://doi.org/10.3949/ccjm.93a.26003
        • Clonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.

      • Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline

        Paru S. David, MD, MSCP, Hannah Nordhues, MD, MSCP and Suneela Vegunta, MD, MSCP
        • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 297-303;
        • DOI: https://doi.org/10.3949/ccjm.93a.25049
        • Sex-specific factors like adverse pregnancy outcomes and premature and early menopause play a critical and often underrecognized role in shaping lifetime stroke risk in women.