More articles from Commentary

  • Primary aldosteronism: Interpreting the 2025 Endocrine Society clinical practice guideline update

    CME Image
    Nandhini Bindukumari Sureshkumar, MD, Marguerite O. Linz, MD, Pratibha PR Rao, MD, MPH and Ricardo Correa, MD, EdD
    • Cleveland Clinic Journal of Medicine September 2026, 93 (9) 515-522;
    • DOI: https://doi.org/10.3949/ccjm.93a.25107
    • The new guideline agrees with growing evidence that primary aldosteronism is common, often missed, and treatable.

  • Comfort care: Creating a plan for hospitalized patients and their families

    Kelly Ferraro, MD, Melissa Morris, DNP and Kimberly A. Indovina, MD
    • Cleveland Clinic Journal of Medicine July 2026, 93 (7) 389-395;
    • DOI: https://doi.org/10.3949/ccjm.93a.25109
    • Comfort care plans are always individualized and should naturally evolve as the patient’s clinical status changes.

  • Hyperactive delirium in hospitalized older adults: Balancing medication choices and QTc prolongation risk

    Emily Hao, MD, Tamara Lhungay, MD, Jessica Arabi, PharmD, BCCCP, Colin J. Harrington, MD and Iva Neupane, MD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 325-330;
    • DOI: https://doi.org/10.3949/ccjm.93a.25092
    • Medications for managing delirium symptoms, particularly antipsychotics, are associated with prolongation of the QT interval, which is a risk factor for the development of fatal arrhythmias.

  • Fighting ageism: Preserving patient agency in critical care

    Astefanos Al-Dalakta, MD, Ruth Diana Lee, MD, Chadi Tabaja, MD, Issam Motairek, MD and Eduardo Mireles-Cabodevila, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 263-265;
    • DOI: https://doi.org/10.3949/ccjm.93a.25105
    • To avoid falling into ageism bias, we must maintain a framework grounded in respect for the patient, one that deliberately centers on the patient’s voice.

  • Alpha-1 antitrypsin deficiency: A persistently underrecognized condition

    James K. Stoller, MD, MS
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 153-157;
    • DOI: https://doi.org/10.3949/ccjm.93a.25103
    • Detecting alpha-1 antitrypsin deficiency early is imperative because diagnostic delay is associated with harm, including worsened clinical status and impaired survival.

  • Preventing cirrhosis: Why primary care clinicians should screen for liver disease in patients who drink heavily

    Pranay Nadella, MD, MPhil, Esperance Schaefer, MD, MPH and Clare Landefeld, MD, MS
    • Cleveland Clinic Journal of Medicine February 2026, 93 (2) 88-93;
    • DOI: https://doi.org/10.3949/ccjm.93a.25045
    • Clinicians in the primary care setting can identify patients with heavy alcohol use and alcohol-related liver disease before they develop advanced liver damage.

  • Suzetrigine: A novel nonopioid systemic analgesic

    Anthony E. Divito, MD, Matthew Sharobeem, DO, Gausan R. Bajracharya, MD and Basem B. Abdelmalak, MD
    • Cleveland Clinic Journal of Medicine February 2026, 93 (2) 94-98;
    • DOI: https://doi.org/10.3949/ccjm.93a.25087
    • The systemic sodium channel blocker suzetrigine may serve as another option for multimodal postoperative analgesia regimens and for managing acute nonsurgical pain.

  • Vaccine hesitancy: Where are we heading?

    Sherif Beniameen Mossad, MD
    • Cleveland Clinic Journal of Medicine January 2026, 93 (1) 21-26;
    • DOI: https://doi.org/10.3949/ccjm.93a.25104
    • Vaccination recently was hailed as one of the top 10 public health achievements of the 20th century; now, the World Health Organization lists vaccine hesitancy among the top 10 threats to global health.

  • Failure to thrive in hospitalized older adults: More than a ‘social admission’

    Shoshana Streiter, MD and Samir Tulebaev, MD
    • Cleveland Clinic Journal of Medicine November 2025, 92 (11) 662-666;
    • DOI: https://doi.org/10.3949/ccjm.92a.25033
    • Failure to thrive documented as an admitting diagnosis presents an opportunity to identify, articulate, and begin to ameliorate the true underlying causes of the patient’s health deficits.

  • Benzodiazepines: Caught between patient needs and guidelines

    Jasleen Kaur, MD, Vania Modesto-Lowe, MD, MPH and Margaret M. Chaplin, MD
    • Cleveland Clinic Journal of Medicine September 2025, 92 (9) 531-535;
    • DOI: https://doi.org/10.3949/ccjm.92a.25019
    • Negative sentiment about benzodiazepines has intensified in recent years, and there is increasing emphasis on deprescribing even for people who have had no ill effects from them.

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