More articles from From the Editor

  • A historical irony—quantitative measurement in critically ill patients is not a panacea

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine October 2026, 93 (10) 575-576;
    • DOI: https://doi.org/10.3949/ccjm.93b.10026
    • Some diagnostic tools that were supposed to render the bedside examination less relevant have themselves failed the test of necessity; meanwhile, the bedside skills they supposedly would displace have also atrophied.

  • Gluten-related disease—more than a gut punch

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine September 2026, 93 (9) 503-504;
    • DOI: https://doi.org/10.3949/ccjm.93b.09026
    • Patients with celiac disease or other gluten-sensitivity disorders have a documented increase in objective findings of systemic autoimmune disease and autoantibodies.

  • Postinfectious immunologic syndromes

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine August 2026, 93 (8) 447-448;
    • DOI: https://doi.org/10.3949/ccjm.93b.08026
    • Activation of the immune system can be associated with many off-target manifestations.

  • Localized dead bone, a potential hint to an underlying condition

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine July 2026, 93 (7) 375-376;
    • DOI: https://doi.org/10.3949/ccjm.93b.07026
    • The discovery of osteonecrosis by imaging, whether the patient is symptomatic or not, warrants consideration for the presence of an underlying condition.

  • Pseudocellulitis, a vague term for a specific diagnostic challenge

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 313-314;
    • DOI: https://doi.org/10.3949/ccjm.93b.06026
    • There are infectious, vascular, and inflammatory conditions that can mimic cellulitis sufficiently to prompt admission and initial treatment with intravenous antibiotics.

  • ‘Even when the wound is healed, the scar remains’

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 255-256;
    • DOI: https://doi.org/10.3949/ccjm.93b.05026
    • Persistent or repetitive inflammatory or ischemic insults to internal organs may lead to progressive scarring that culminates in organ failure.

  • ‘All that wheezes is not asthma’—a reminder that the physical examination

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195;
    • DOI: https://doi.org/10.3949/ccjm.93b.04026
    • In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

  • Getting stuck on a name: An example of an eponymous syndrome

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 131-132;
    • DOI: https://doi.org/10.3949/ccjm.93b.03026
    • Debate continues about whether we should continue to use eponymous diagnostic nomenclature or shift entirely to an anatomic or pathophysiologic descriptive terminology.

  • A new direction in pain management?

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine February 2026, 93 (2) 67-68;
    • DOI: https://doi.org/10.3949/ccjm.93b.02026
    • It would be nice to have a treatment option for pain that is less limited by side effects, cognitive dysfunction, addiction potential, and red tape.

  • More on the myths and perceived magic of corticosteroids

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine January 2026, 93 (1) 6-7;
    • DOI: https://doi.org/10.3949/ccjm.93b.01026
    • It is widely accepted that corticosteroids can partially prevent infusion reactions to intravenous diagnostic and therapeutic agents, but evidence to support this concept is scant.

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