Drug Therapy

The systemic sodium channel blocker suzetrigine may serve as another option for multimodal postoperative analgesia regimens and for managing acute nonsurgical pain.

Potassium-competitive acid blockers are reserved for patients who cannot tolerate proton pump inhibitors or who do not respond to them.

It would be nice to have a treatment option for pain that is less limited by side effects, cognitive dysfunction, addiction potential, and red tape.

A better understanding of the pathophysiology of this autoimmune disorder has led to innovative insights into its treatment, but long-term management remains a challenge.

Initial enthusiasm for teprotumumab as therapy for thyroid eye disease has been tempered by longitudinal data suggesting that it often does not alter the natural disease course.

Oral norgestrel, the first daily oral contraceptive pill available over the counter in the United States, is a safe, effective addition to existing over-the-counter contraceptive options.

The authors discuss current evidence-based approaches to managing hypertension and optimizing blood pressure control through a series of cases representing common clinical scenarios.

Negative sentiment about benzodiazepines has intensified in recent years, and there is increasing emphasis on deprescribing even for people who have had no ill effects from them.

Discontinuation of benzodiazepines in chronic users may be associated with a small increase in mortality and a higher risk of adverse events, especially in the short term after cessation.

The authors review the potential effects, risks, and therapeutic applications of the psychedelic drugs MDMA (Ecstasy) and psilocybin, with a focus on MDMA-assisted therapy for posttraumatic stress disorder and psilocybin-assisted therapy for depression.