Hematology

Letter: The intersection of CHIP and HIV: Implications for cardiovascular risk stratification
Abigail Martinez, MD, Hector Bolivar, MD and Marco A. Ruiz, MD
- Cleveland Clinic Journal of Medicine August 2026, 93 (8) 451;
- DOI: https://doi.org/10.3949/ccjm.93c.08001
When should I order the serum free light-chain assay, and how should I interpret mild kappa or lambda elevations?
Malvinder S. Parmar, MB, MS
- Cleveland Clinic Journal of Medicine August 2026, 93 (8) 459-462;
- DOI: https://doi.org/10.3949/ccjm.93a.26009
- Reserve the test for scenarios where a plasma cell disorder is clinically suspected, and interpret mild elevations through the lenses of the kappa:lambda ratio and patient context.
In Reply: The intersection of CHIP and HIV: Implications for cardiovascular risk stratification
Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
- Cleveland Clinic Journal of Medicine August 2026, 93 (8) 451-452;
- DOI: https://doi.org/10.3949/ccjm.93c.08002
In Reply: Diagnostic challenges in severe autoimmune hemolysis
Sindu Iska, MD, María Herrán, MD, You Li, MD, Maria Teresa Bejarano, MD, Chakra P. Chaulagain, MD and Chieh-Lin Fu, MD
- Cleveland Clinic Journal of Medicine June 2026, 93 (6) 317-318;
- DOI: https://doi.org/10.3949/ccjm.93c.06002
Letter: Diagnostic challenges in severe autoimmune hemolysis
Sadeem Muhammad Rizwan, MBBS
- Cleveland Clinic Journal of Medicine June 2026, 93 (6) 317;
- DOI: https://doi.org/10.3949/ccjm.93c.06001
Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
- Cleveland Clinic Journal of Medicine May 2026, 93 (5) 289-295;
- DOI: https://doi.org/10.3949/ccjm.93a.26003
- Clonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.
A 24-year-old man with severe hemolytic anemia and variable Coombs test results
Sindu Iska, MD, María Herrán, MD, You Li, MD, Maria Teresa Bejarano, MD, Chakra P. Chaulagain, MD and Chieh-Lin Fu, MD
- Cleveland Clinic Journal of Medicine March 2026, 93 (3) 159-168;
- DOI: https://doi.org/10.3949/ccjm.93a.25079
- The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.
Should every patient with an unprovoked venous thromboembolism have a hypercoagulable workup?
Jaime Tan, MD, Neeladri Misra, MD and Sivakumar Reddy, MD
- Cleveland Clinic Journal of Medicine September 2024, 91 (9) 531-533;
- DOI: https://doi.org/10.3949/ccjm.91a.24016
- In the absence of consensus guidelines addressing this question, an individualized approach that considers personal and family history is needed.
Stop the clot: When is laboratory evaluation for thrombophilia warranted?
Jaideep Singh Bhalla, MD, G. Jay Bishop, MD and Scott J. Cameron, MD, PhD
- Cleveland Clinic Journal of Medicine September 2024, 91 (9) 535-536;
- DOI: https://doi.org/10.3949/ccjm.91a.24058
- Evidence does not support routine testing for an underlying hereditary thrombophilia after an arterial or venous thrombosis. Instead, the benefits of testing must be discussed with each patient.
Gingival overgrowth in acute monocytic leukemia
Lex Leonhardt, DO, John Harcha, MD and Alejandro Calvo, MD, FACP
- Cleveland Clinic Journal of Medicine May 2024, 91 (5) 267-268;
- DOI: https://doi.org/10.3949/ccjm.91a.23087
- A 55-year-old man presented to the emergency department with a 2-month history of progressive gingival swelling and oral pain.