Mental Health

  • How can I differentiate delirium from altered mental status in hospitalized older adults?

    Asim Kichloo, MD, Calista Hemarga, BS, Ivan Magallanes Marrufo, MPH and Sandra Davis, MD
    • Cleveland Clinic Journal of Medicine October 2026, 93 (10) 581-585;
    • DOI: https://doi.org/10.3949/ccjm.93a.26025

    • Bedside screening tools can be used to distinguish delirium from other causes of altered mental status, enabling timely care and reducing costs.

  • Kratom at a crossroads: Trends, controversies, and the evidence gap

    Vania Modesto-Lowe, MD, MPH, Deanna Sgambato, DMS, MHS, PA-C, Jasleen Kaur, MD and Margaret Chaplin, MD
    • Cleveland Clinic Journal of Medicine August 2026, 93 (8) 487-492;
    • DOI: https://doi.org/10.3949/ccjm.93a.25088

    • Amid the opioid crisis, kratom use has grown for self-management of pain, mood symptoms, and opioid withdrawal.

  • In Reply: Olanzapine in Parkinson disease and dementia with Lewy bodies

    Emily Hao, MD, Tamara Lhungay, MD, Jessica Arabi, PharmD, BCCCP, Colin J. Harrington, MD and Iva Neupane, MD
    • Cleveland Clinic Journal of Medicine August 2026, 93 (8) 453;
    • DOI: https://doi.org/10.3949/ccjm.93c.08004

  • Letter: Olanzapine in Parkinson disease and dementia with Lewy bodies

    Enmanuel A. Leiva-Murillo, MD and Jazmín Olmedo-Alvariza, MD
    • Cleveland Clinic Journal of Medicine August 2026, 93 (8) 452-453;
    • DOI: https://doi.org/10.3949/ccjm.93c.08003

  • When risks outweigh benefits: A review of the guideline on benzodiazepine tapering

    CME Image
    Hannah Snyder, MD, David Streem, MD, Akhil Anand, MD and Adele C. Viguera, MD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 347-352;
    • DOI: https://doi.org/10.3949/ccjm.93a.25102

    • The new joint clinical practice guideline provides a framework for deciding when tapering is appropriate and for implementing safe, patient-centered discontinuation strategies.

  • Hyperactive delirium in hospitalized older adults: Balancing medication choices and QTc prolongation risk

    Emily Hao, MD, Tamara Lhungay, MD, Jessica Arabi, PharmD, BCCCP, Colin J. Harrington, MD and Iva Neupane, MD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 325-330;
    • DOI: https://doi.org/10.3949/ccjm.93a.25092

    • Medications for managing delirium symptoms, particularly antipsychotics, are associated with prolongation of the QT interval, which is a risk factor for the development of fatal arrhythmias.

  • Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options

    Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205;
    • DOI: https://doi.org/10.3949/ccjm.93a.25052

    • In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • Treating perinatal mood and anxiety disorders: A call to action

    Lulu Zhao, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 207-209;
    • DOI: https://doi.org/10.3949/ccjm.93a.26002

    • Perinatal mood and anxiety disorders remain untreated in 3 of 4 affected individuals giving birth.

  • Chronic ocular pain

    Radhika S. Amin, Eliot N. Haddad and Rony R. Sayegh, MD
    • Cleveland Clinic Journal of Medicine November 2025, 92 (11) 652;
    • DOI: https://doi.org/10.3949/ccjm.92c.11003

  • Benzodiazepines: Caught between patient needs and guidelines

    Jasleen Kaur, MD, Vania Modesto-Lowe, MD, MPH and Margaret M. Chaplin, MD
    • Cleveland Clinic Journal of Medicine September 2025, 92 (9) 531-535;
    • DOI: https://doi.org/10.3949/ccjm.92a.25019

    • Negative sentiment about benzodiazepines has intensified in recent years, and there is increasing emphasis on deprescribing even for people who have had no ill effects from them.

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