Neurology

  • How can I differentiate delirium from altered mental status in hospitalized older adults?

    Asim Kichloo, MD, Calista Hemarga, BS, Ivan Magallanes Marrufo, MPH and Sandra Davis, MD
    • Cleveland Clinic Journal of Medicine October 2026, 93 (10) 581-585;
    • DOI: https://doi.org/10.3949/ccjm.93a.26025
    • Bedside screening tools can be used to distinguish delirium from other causes of altered mental status, enabling timely care and reducing costs.

  • Acute vertigo in a 67-year-old woman: Peripheral or central?

    David Kweku Aseda Donkor, MD, Kapil Nayar, MD and Jerma Adams, MD
    • Cleveland Clinic Journal of Medicine October 2026, 93 (10) 592-596;
    • DOI: https://doi.org/10.3949/ccjm.93a.26035
    • The patient presented with dizziness that started earlier that morning when she rose from bed, persisted after she returned to bed, and worsened with head movement.

  • When is brain MRI with and without contrast indicated for evaluation of headache?

    NJ Abdallah, DO and Madisen Olson, DO, MBA
    • Cleveland Clinic Journal of Medicine August 2026, 93 (8) 463-466;
    • DOI: https://doi.org/10.3949/ccjm.93a.25106
    • Secondary headache disorders such as neoplasm or infection are more often suspected than detected, but neuroimaging is warranted when red-flag features are present.

  • A 70-year-old man with lower-extremity weakness and falls

    Calen Frolkis, MD, Ari Wachsman, MD, Angela Liu, MD, PhD and Ayoub Harb, DO
    • Cleveland Clinic Journal of Medicine July 2026, 93 (7) 409-417;
    • DOI: https://doi.org/10.3949/ccjm.93a.25061
    • After multiple imaging studies were performed, a thorough examination at the bedside appropriately broadened the differential diagnosis.

  • Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline

    Paru S. David, MD, MSCP, Hannah Nordhues, MD, MSCP and Suneela Vegunta, MD, MSCP
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 297-303;
    • DOI: https://doi.org/10.3949/ccjm.93a.25049
    • Sex-specific factors like adverse pregnancy outcomes and premature and early menopause play a critical and often underrecognized role in shaping lifetime stroke risk in women.

  • TOC Icon

    A young woman with Kallmann syndrome and acute neurologic symptoms

    Jumaina F. Ali, MBChB, Adhithya Sankar, MBChB, PhD, Mohammed S. O. Ahmed, MBBS, MSc, Mark Woodward, BSc (Hons), MBChB and Akheel A. Syed, MBBS, PhD
    • Cleveland Clinic Journal of Medicine January 2026, 93 (1) 29-34;
    • DOI: https://doi.org/10.3949/ccjm.93a.25010
    • Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.

  • Trident sign in osmotic demyelination syndrome

    Erin Equinozzi, MSc, Clement D. Lee, MD, MSc and Pamela Schaefer, MD
    • Cleveland Clinic Journal of Medicine December 2025, 92 (12) 732-733;
    • DOI: https://doi.org/10.3949/ccjm.92a.24080
    • Brain magnetic resonance imaging showed a confluent trident-shaped lesion in the central pons 1 week after correction of the patient’s chronic hyponatremia.

  • MDA5 dermatomyositis: Unveiling a potentially life-threatening disease

    Soumya Chatterjee, MD, MS
    • Cleveland Clinic Journal of Medicine October 2025, 92 (10) 627-637;
    • DOI: https://doi.org/10.3949/ccjm.92a.25018
    • Timely diagnosis and initiation of aggressive immunosuppressive therapy are key to improving the 40% overall mortality rate in patients with MDA5 dermatomyositis.

  • TOC Icon

    Cerebrovascular complications in infective endocarditis: Challenges and considerations in management

    Vikyath Satish, MD, Maisha Maliha, MD, Abhyuday Chauhan, MD, Nieves del Mar Morales-Gomez, MD, Safwan Gaznabi, MD, Daniel Lorenzatti, MD, Justin Johannesen, MD, Carlos A. Gongora, MD, Annalisa Filtz, MD, Mario J. Garcia, MD, Leandro Slipczuk, MD, PhD and Aldo L. Schenone, MD
    • Cleveland Clinic Journal of Medicine August 2025, 92 (8) 491-501;
    • DOI: https://doi.org/10.3949/ccjm.92a.24087
    • Although the cerebrovascular complications of infective endocarditis such as ischemic strokes and intracranial hemorrhages are common and serious, data remain scarce regarding how best to prevent, predict, and manage them.

  • TOC Icon

    Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management

    Albert Aboseif, DO, J. Daniel Bireley, MD, Yuebing Li, MD, PhD, David Polston, MD and Justin R. Abbatemarco, MD
    • Cleveland Clinic Journal of Medicine July 2023, 90 (7) 439-447;
    • DOI: https://doi.org/10.3949/ccjm.90a.22093
    • A review of the presentation and diagnostic evaluation, including atypical features that may suggest an alternative diagnosis requiring a more extensive evaluation.

Previous