Pain

  • Suzetrigine: A novel nonopioid systemic analgesic

    Anthony E. Divito, MD, Matthew Sharobeem, DO, Gausan R. Bajracharya, MD and Basem B. Abdelmalak, MD
    • Cleveland Clinic Journal of Medicine February 2026, 93 (2) 94-98;
    • DOI: https://doi.org/10.3949/ccjm.93a.25087
    • The systemic sodium channel blocker suzetrigine may serve as another option for multimodal postoperative analgesia regimens and for managing acute nonsurgical pain.

  • A new direction in pain management?

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine February 2026, 93 (2) 67-68;
    • DOI: https://doi.org/10.3949/ccjm.93b.02026
    • It would be nice to have a treatment option for pain that is less limited by side effects, cognitive dysfunction, addiction potential, and red tape.

  • Chronic ocular pain

    Radhika S. Amin, Eliot N. Haddad and Rony R. Sayegh, MD
    • Cleveland Clinic Journal of Medicine November 2025, 92 (11) 652;
    • DOI: https://doi.org/10.3949/ccjm.92c.11003
  • Nociplastic pain: A practical guide to chronic pain management in the primary care setting

    Rupak Thapa, MD and Dennis Ang, MD
    • Cleveland Clinic Journal of Medicine April 2025, 92 (4) 236-247;
    • DOI: https://doi.org/10.3949/ccjm.92a.24101
    • Nociplastic pain is characterized by amplification of pain transmission and pain perception and does not involve visible tissue injury or damage, which makes it difficult to understand and manage.

  • A practical guide for buprenorphine initiation in the primary care setting

    Roberto León-Barriera, MD, Samantha Jayne Zwiebel, MD, MA and Vania Modesto-Lowe, MD, MPH
    • Cleveland Clinic Journal of Medicine September 2023, 90 (9) 557-564;
    • DOI: https://doi.org/10.3949/ccjm.90a.23022
    • The authors review changes in prescribing laws and outline buprenorphine induction protocols that can be adopted in the primary care setting.

  • Guidelines for the management of trigeminal neuralgia

    Mun Seng Chong, MBBS, MD, FRCP, Anish Bahra, MBChB, MD, FRCP and Joanna M. Zakrzewska, BDS, MB BChir, MD, FDSRCS, FFDRCSI, FFPM RCA, FHEA
    • Cleveland Clinic Journal of Medicine June 2023, 90 (6) 355-362;
    • DOI: https://doi.org/10.3949/ccjm.90a.22052
    • Care pathways for patients with trigeminal neuralgia vary widely. The most recent UK guidelines emphasize the need for evidence-based care plans for multidisciplinary management.

  • Central sensitization, chronic pain, and other symptoms: Better understanding, better management

    Mary M. Volcheck, MSN, RN, Stephanie M. Graham, RN, Kevin C. Fleming, MD, Arya B. Mohabbat, MD and Connie A. Luedtke, RN, PMGT-BC
    • Cleveland Clinic Journal of Medicine April 2023, 90 (4) 245-254;
    • DOI: https://doi.org/10.3949/ccjm.90a.22019
    • Clinicians have a pivotal role by providing patient education, which can affect perception, management, functional status, and quality of life.

  • Chronic centralized pain syndromes: A rheumatologist’s perspective

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2023, 90 (4) 201-202;
    • DOI: https://doi.org/10.3949/ccjm.90b.04023
    • Centralized pain syndromes are vexing for patients and clinicians. In this issue, Volcheck and colleagues present a framework for understanding chronic centralized pain and for developing an actionable treatment plan for patients.

  • How do I interpret and use quantitative buprenorphine and norbuprenorphine urine levels?

    Richard C. Waters, MD, MSc and Matthew Perez, MD
    • Cleveland Clinic Journal of Medicine October 2022, 89 (10) 557-560;
    • DOI: https://doi.org/10.3949/ccjm.89a.21019
    • Confirmatory testing of urine samples can be useful in outpatient settings where buprenorphine dosing is not directly observed. But retaining and engaging the patient in effective treatment should be the ultimate goals of testing.

  • Psychogenic nonepileptic seizure: An empathetic, practical approach

    Becky Bikat S. Tilahun, PhD and Jocelyn F. Bautista, MD
    • Cleveland Clinic Journal of Medicine May 2022, 89 (5) 252-259;
    • DOI: https://doi.org/10.3949/ccjm.89a.21109
    • Barriers to care include clinician misperceptions, lack of acceptance of the diagnosis, poor patient engagement with treatment, and lack of access to care.

Previous